期刊
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
卷 83, 期 11, 页码 2557-2571出版社
WILEY
DOI: 10.1111/bcp.13364
关键词
antibiotics; cardiac defect; craniosynostosis; major congenital malformations; pregnancy
资金
- Reseau Quebecois de recherche sur l'usage des medicaments
- Sainte-Justine Hospital Foundation
- Foundation of Stars scholarship from the Faculty of Pharmacy of the University of Montreal
- Canadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM)
- FRSQ
AimsFew studies have investigated the link between individual antibiotics and major congenital malformations (MCMs) including specific malformations owing to small sample size. We aimed to quantify the association between exposure to gestational antibiotic and the risk of MCMs. MethodsUsing the Quebec pregnancy cohort (1998-2008), we included a total of 139938 liveborn singleton alive whose mothers were covered by the Regie de l'assurance maladie du Quebec drug plan for at least 12 months before and during pregnancy. Antibiotic exposure was assessed in the first trimester and MCMs were identified within the first year of life. ResultsAfter adjusting for potential confounders, clindamycin exposure was associated with an increased risk of MCMs (aOR 1.34, 95% CI 1.02-1.77, 60 exposed cases), musculoskeletal system malformations (aOR 1.67, 95% CI 1.12-2.48, 29 exposed cases) and ventricular/atrial septal defect (aOR 1.81, 95% CI 1.04-3.16, 13 exposed cases). Doxycycline exposure increased the risk of circulatory system malformation, cardiac malformations and ventricular/atrial septal defect (aOR 2.38, 95% CI 1.21-4.67, 9 exposed cases; aOR 2.46, 95% CI 1.21-4.99, 8 exposed cases; aOR 3.19, 95% CI 1.57-6.48, 8 exposed cases, respectively). Additional associations were seen with quinolone (1 defect), moxifloxacin (1 defect), ofloxacin (1 defect), macrolide (1 defect), erythromycin (1 defect) and phenoxymethylpenicillin (1 defect). No link was observed with amoxicillin, cephalosporins and nitrofurantoin. Similar results were found when penicillins were used as the comparator group. ConclusionsClindamycin, doxycycline, quinolones, macrolides and phenoxymethylpenicillin in utero exposure were linked to organ-specific malformations. Amoxicillin, cephalosporins and nitrofurantoin were not associated with MCMs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据