期刊
CANCER LETTERS
卷 407, 期 -, 页码 139-147出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.05.025
关键词
Competing endogenous RNA; Circular RNA; Anti-miRNA oligonucleotide; miRNA sponge; Nanoparticle; Gene therapy
类别
资金
- National Natural Science Foundation of China [81502132]
MicroRNA (miRNAs) is post-transcriptional regulator of mRNA. However, the prevalence and activity of miRNA are regulated by other regulators. miRNA inhibitors are natural or artificial RNA transcripts that sequestrate miRNAs and decrease or even eliminate miRNA activity. Competing endogenous RNAs (ceRNAs) are natural and intracellular miRNA inhibitors that compete to bind to shared miRNA recognition elements (MREs) to decrease microRNA availability and relieve the repression of target RNAs. In recent years, studies have revealed that ceRNA crosstalk is involved in many pathophysiological processes and adds a new dimension to miRNA regulation. Artificial miRNA inhibitors are RNA transcripts that are synthesized via chemical and genetic methods. Artificial miRNA inhibitors can be used in miRNA loss-of-function research and gene therapies for certain diseases. In this review, we summarize the recent advances in the two different types of miRNA inhibitors. (C) 2017 Elsevier B.V. All rights reserved.
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