期刊
CELL
卷 171, 期 3, 页码 507-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2017.08.050
关键词
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资金
- European Research Council [GRIDCODE - 338865, ENSEMBLE - 268598]
- Research Council of Norway (RCN) [226003/H10]
- RCN (Centre for Neural Computation) [223262, 197467]
- Kavli Foundation
The medial entorhinal cortex (MEC) contains several discrete classes of GABAergic interneurons, but their specific contributions to spatial pattern formation in this area remain elusive. We employed a pharmacogenetic approach to silence either parvalbumin (PV)-or somatostatin (SOM)-expressing interneurons while MEC cells were recorded in freely moving mice. PV-cell silencing antagonized the hexagonally patterned spatial selectivity of grid cells, especially in layer II of MEC. The impairment was accompanied by reduced speed modulation in colocalized speed cells. Silencing SOM cells, in contrast, had no impact on grid cells or speed cells but instead decreased the spatial selectivity of cells with discrete aperiodic firing fields. Border cells and head direction cells were not affected by either intervention. The findings point to distinct roles for PV and SOM interneurons in the local dynamics underlying periodic and aperiodic firing in spatially modulated cells of the MEC.
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