期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 27, 期 20, 页码 4777-4780出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.07.034
关键词
Lachnum polysaccharide; Carboxymethylation; Anti-fatigue activity
资金
- National Natural Science Foundation of China [31470146]
- Scientific and Technological Research Foundation of Anhui Province of China [12010302071]
The present study was designed to evaluate the anti-fatigue activity of an exopolysaccharide LEP-1 b and its carboxymethylated derivative CLEP-1b from a Lachnum sp. Carboxymethylation was confirmed through FT-IR and C-13 NMR spectroscopies, which showed that the (-CH2COOH) group was attached to an oxygen (O) atom of the hydroxyl group on (C-3) of LEP-1b. Each treatment group LEP-lb and CLEP-1b at doses (50, 100, 200 mg/kg, respectively) ameliorated physical fatigue and extended exhaustive swimming time in mice. Results of the fatigue related biochemical markers showed that LEP-1b and CLEP-1b at doses (50, 100, 200 mg/kg, respectively) increased the content of hepatic glycogen and decreased the level of serum urea nitrogen and lactic acid. Additionally, LEP-1b and CLEP-1b enhanced the antioxidant enzymes' activities and reduced the lipid peroxidation. Moreover, results revealed that CLEP-1b had higher anti-fatigue activity than LEP-lb at same doses but without statistical significance, especially CLEP-1b (200 mg/kg) had strong anti-fatigue effects. Therefore, LEP-1b and CLEP-1b can potentially be exploited as a kind of healthcare compound to combat fatigue and to boost physical strength. (C) 2017 Published by Elsevier Ltd.
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