期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 79, 页码 10950-10953出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc05832b
关键词
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资金
- National Natural Science Foundation of China [91427304, 21434007, 21574122, 51573175, 21404098]
- Fundamental Research Funds for the Central Universities [WK3450000002, WK2060200017]
- State Key Laboratory of Polymer Physics and Chemistry (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)
A new model using a gold nanoparticle (AuNP)-DNA system to constrain leakage and improve efficiency of catalytic toehold-mediated strand displacement reactions was outlined. A 10-bp spacer on AuNPs and fourfold amount of fuels were determined for good performance of this model with an optimized toehold strategy. After the reaction at 25 degrees C for 10 h, a 258 pM target could be identified, which is a remarkable improvement compared with the traditional AuNP-DNA system without fuel. Moreover, this model was also studied to differentiate specific single nucleotide polymorphism on target with superior selection factors. This model may help by introducing a proposition of target detection to guide further investigation.
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