期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 56, 页码 14017-14026出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201702975
关键词
carbenes; glycoconjugates; gold; photodynamic therapy; porphyrinoids
资金
- Ministere de l'Education Nationale de l'Enseignement Superieur et de la Recherche of France
- Agence Nationale de la Recherche [ANR-09-JCJC-0089-01]
- Region Lan-guedoc-Roussillon [2013-098085, 2015-005984]
- FEDER (Fonds Europeen de Developpement Regional)
- Agence Nationale de la Recherche (ANR) [ANR-09-JCJC-0089] Funding Source: Agence Nationale de la Recherche (ANR)
Porphyrins fused to imidazolium salts across two neighboring beta-pyrrolic positions were used as N-heterocyclic carbene (NHC) precursors to anchor Au-I-Cl complexes at their periphery. Synthesis of several thiolato-Au-I complexes was then achieved by substituting chloride for thiolates. Photodynamic properties of these complexes were investigated: the data obtained show that the Au-S bonds could be cleaved upon irradiation. The proposed mechanism to explain the release of thiolate moiety involves the S atom oxidation by singlet oxygen generated in the course of irradiation. In view of photodynamic therapy (PDT) applications, these porphyrins fused to NHC-Au-I complexes were tested as photosensitizers to kill MCF-7 breast cancer cells. Results show the important role played by the ancillary ligands (chloride versus thiolates) on the photodynamic effect.
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