期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 56, 页码 14080-14089出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201703229
关键词
cascade cyclization; cyclotrimerization; natural products; total synthesis; transition-metal catalysis
资金
- EPSRC [EP/E055273/1, EP/K005391/1]
- Marie Sklodowska-Curie actions [656012]
- A*STAR
- German Academic Exchange Service
- Marie Curie Actions (MSCA) [656012] Funding Source: Marie Curie Actions (MSCA)
Full details of the total synthesis of the Schisandraceae nortriterpenoid natural product rubriflordilactone A are reported. Palladium- and cobalt-catalyzed polycyclizations were employed as key strategies to construct the central pentasubstituted arene from bromoendiyne and triyne precursors. This required the independent assembly of two AB ring aldehydes for combination with a common diyne component. A number of model systems were explored to investigate these two methodologies, and also to establish routes for the installation of the challenging benzopyran and butenolide rings.
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