期刊
BIOCHEMISTRY
卷 56, 期 39, 页码 5178-5184出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.7b00435
关键词
-
资金
- National Science Foundation [DGE-1321846]
- National Institutes of Health [R01 GM107630]
Bioluminescence with luciferase-luciferin pairs is an attractive method for surveying cells in live tissues and whole organisms. Recent advances in luciferin chemistry and luciferase engineering are further expanding the scope of the technology. It is now possible to spy on cells in a variety of deep tissues and visualize multicellular interactions, feats that are enabling new questions to be asked and new ideas to be explored. This perspective piece highlights recent successes in bioluminescent probe development and their applications to imaging in live cells, tissues, and animals.
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