期刊
BIOCONJUGATE CHEMISTRY
卷 28, 期 10, 页码 2575-2580出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.7b00416
关键词
-
类别
资金
- Welch Foundation [H-Q-0042]
- Cancer Prevention Research Institute of Texas (CPRIT) [RP160805]
DNA-encoded: chemical libraries have emerged as a cost-effective alternative to high-throughput screening (HTS) for hit identification in drug discovery. A key factor for productive DNA-encoded libraries is the chemical diversity of the small molecule moiety attached to an encoding DNA oligomer. The library structure diversity is often limited to DNA-compatible chemical reactions in aqueous media. Herein, we describe a facile process for reducing aryl nitro groups to aryl amines. The new protocol offers simple operation and circumvents the pyrophoric potential of the conventional method (Raney nickel). The reaction is performed in aqueous solution and does not compromise DNA structural integrity. The utility of this method is demonstrated by the versatile synthesis of benzimidazoles on DNA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据