期刊
VACCINE
卷 35, 期 21, 页码 2794-2800出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.04.019
关键词
Streptococcus pneumoniae; Nasopharyngeal carriage; Serotypes; Antimicrobial resistance; Pneumococcal conjugate vaccines
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Science without Borders program
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Pro-Reitoria de Pesquisa, Pos-Graduacao e Inovacao da Universidade Federal Fluminense (PROPPi/UFF)
Background: In 2010, the 10-valent pneumococcal conjugate vaccine (PCV10) was introduced free of charge in Brazil as part of the public immunization program. Here we investigated the carriage prevalence, colonization risk factors, capsular types, and antimicrobial resistance among pneumococcal isolates obtained from children in Brazil four years after routine PCV10 use. Methods: Between September and December 2014, we conducted a cross-sectional study among children < 6 years old who attended one public and two private clinics in Niteroi, RJ, Brazil to evaluate pneumococcal nasopharyngeal carriage. Antimicrobial susceptibility and capsular types were determined for all isolates. Results: Of 522 children, 118 (22.6%) were pneumococcal carriers. Being >= 2 years old, attending childcare center, presenting with any symptoms, having acute or chronic respiratory disease, and residing in a slum were associated with pneumococcal carriage. The most prevalent capsular types were 6C (14.5%), 15B/C (11.5%), 11A/D (9.2%), and 6A (7.6%). PCV10 serotypes represented 2.5%. All isolates were susceptible to levofloxacin, rifampicin, and vancomycin. Penicillin non-susceptible pneumococci (PNSP) comprised 39%, with penicillin and ceftriaxone MICs ranging from 0.12-8.0 mu g/ml and 0.012-1.0 mu g/ml, respectively. The 33 (28%) erythromycin-resistant isolates (MICs of 1.5 to >256 mu g/ml) displayed the cMLS(B) (72.7%) or M (273%) phenotypes, harboring the erm(B) and/or mef(A/E) genes. High non susceptibility rates (>20%) to clindamycin, erythromycin, penicillin, and tetracycline were largely explained by the prevalence of multidrug resistant (MDR) serotype 6C isolates. Conclusions: Effects of universal childhood PCV10 use on carriage were evident, with the near elimination of PCV10 serotypes. The emergence of MDR serotype 6C isolates, however, is a concern. Ongoing surveillance to monitor serotype 6C increase in invasive diseases is warranted. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据