期刊
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
卷 51, 期 10, 页码 1000-1009出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0004867417714952
关键词
Schizophrenia; network homogeneity; olanzapine; default-mode network; functional magnetic resonance imaging
类别
资金
- National Natural Science Foundation of China [81571310, 81630033, 81471363]
- National Key Research and Development Program [2016YFC1307100, 2016YFC1306900]
- Natural Science Foundation of Guangxi Province for Distinguished Young Scientists [2014GXNSFGA118010]
Background: Previous studies on brain function alterations associated with antipsychotic treatment for schizophrenia have produced conflicting results because they used short treatment periods and different designs. Methods: Resting-state functional magnetic resonance imaging scans were obtained from 17 drug-free patients with recurrent schizophrenia and 24 healthy controls. The patients were treated with olanzapine for 6 months and were scanned at three time points (baseline, 6 weeks of treatment and 6 months of treatment). Network homogeneity was used to analyze the imaging data to examine default-mode network homogeneity alterations associated with antipsychotic treatment. Results: Compared with the controls, the patients at baseline showed increased network homogeneity in the bilateral precuneus and decreased network homogeneity in the bilateral middle temporal gyrus. Network homogeneity values in the bilateral precuneus decreased, and network homogeneity values in the left superior medial prefrontal cortex and the right middle temporal gyrus increased in patients administered olanzapine as antipsychotic treatment. By contrast, network homogeneity values in the left middle temporal gyrus remained unchanged in patients after treatment. Conclusion: This study provides evidence that antipsychotic treatment with olanzapine modulates the default-mode network homogeneity in schizophrenia. These findings contribute to the understanding of antipsychotic treatment effects on brain functions.
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