期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 207, 期 -, 页码 127-134出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2017.06.002
关键词
Physical activity; Physical exercise; Multiple sclerosis; Oxysterols; Cholesterol; Myelin; Oxidative stress
资金
- ARSEP foundation Paris Descartes University [ARSEP AO_2014, ARSEP AO_2015]
- INSERM
Multiple sclerosis (MS) is a central nervous demyelinating disease characterized by cyclic loss and repair of myelin sheaths associated with chronic inflammation and neuronal loss. This degenerative pathology is accompanied by modified levels of oxysterols (oxidative derivatives of cholesterol, implicated in cholesterol metabolism), highlighted in the brain, blood and cerebrospinal fluid of MS patients. The pathological accumulation of such derivatives is thought to participate in the onset and progression of the disease through their implication in inflammation, oxidative stress, demyelination and neuro-degeneration. In this context, physical exercise is envisaged as a complementary resource to ameliorate therapeutic strategies. Indeed, physical activity exerts beneficial effects on neuronal plasticity, decreases inflammation and oxidative stress and improves blood-brain integrity in extents that could be beneficial for brain health. The present review attempts to summarize the available data on the positive effect of physical exercise to highlight possible links between physical activity and modulation of cholesterol/oxysterol homeostasis in MS. (C) 2017 Elsevier B.V. All rights reserved.
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