期刊
CATALYSIS COMMUNICATIONS
卷 102, 期 -, 页码 108-113出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.catcom.2017.09.001
关键词
One-pot reductive amination; Aldehyde; Nitroarene; Supported copper catalyst; Continuous flow reactor; Molecular hydrogen
资金
- Boreskov Institute of Catalysis [0303-2016-0006]
Supported copper catalysts were investigated for the one-pot reductive amination of aldehydes with nitroarenes in a continuous flow reactor. This process is considered advantageous compared to current traditional methods, which present several drawbacks, such as toxicity of reducing or alkylation agent, lack of monoalkylation selectivity and large amounts of waste produced. Various secondary amines were synthesized in good to excellent yields in the reactions of aliphatic aldehydes with nitroarenes using molecular hydrogen as a reducing agent. It was found that the yield of secondary amine depends on the rate of formation of intermediate imine.
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