期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 158, 期 -, 页码 57-67出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.06.026
关键词
Chitosan; CaTiO3 nanoparticles; Hybrid; Schwann cells; Peripheral nerve regeneration
资金
- National Natural Science Foundation of China [31500782, 81371687]
- Jiangsu Overseas Research & Training Program for University Prominent Young & Middle-aged Teachers and Presidents
- National Key Research and Development Program of China [2016YFC1101600]
- Natural Science Foundation of Jiangsu Province of China [BK20140429]
- Project by Key Laboratory of Advanced Technologies Materials, Ministry of Education [2016KLATM001]
- Natural Science Foundation of Nantong University [13R23, 14ZY015]
- Nantong University [CXZR201507]
To further improve the property of promoting peripheral nerve regeneration of chitosan materials, CaTiO3 nanoparticles with various concentrations were synthesized in chitosan (CS) solution and formed to porous CS/CaTiO3 hybrid scaffolds. The properties including morphology, wettability, porosity, crystallization intensity and surface charges were characterized, respectively. The influence of the porous CS/CaTiO3 hybrid scaffolds on Schwann cells growth was evaluated. The results showed that the CaTiO3 hybridized CS scaffolds possessed homogeneous nanoparticles distribution with concentration dependent effect. The hybridization of CaTiO3 nanoparticles could increase the hydrophobicity while reduce the porosity and surface charge density of the porous CS/CaTiO3 hybrid scaffolds The crystal structure of the hybridized scaffolds was mainly the orthorhombic structure of the calcium titanate accompanied by the amorphous phase of chitosan. Culture of Schwann cells indicated that the CS/CaTiO3 hybrid scaffolds with a suitable concentration of CaTiO3 nanoparticles could obviously promote the attachment, proliferation and biological function maintenance of Schwann cells, thus showing potentially great significance towards application in peripheral nerve regeneration. (C) 2017 Elsevier B.V. All rights reserved.
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