期刊
CANCER SCIENCE
卷 108, 期 10, 页码 1953-1958出版社
WILEY
DOI: 10.1111/cas.13344
关键词
Cancer; cytoskeleton; MACF1; metastasis; signal pathway
类别
资金
- Fundamental Research Funds for the Central Universities [3102016ZY037]
- China Postdoctoral Science Foundation [2015T81051]
- Shenzhen Science and Technology Project [JCYJ20160229174320053]
- National Natural Science Foundation of China [31400725, 31570940]
Cancer is a polygenic disease characterized by uncontrolled growth of normal body cells, deregulation of the cell cycle as well as resistance to apoptosis. The spectraplakin protein microtubule actin cross-linking factor 1 (MACF1) plays an essential function in various cellular processes, including cell proliferation, migration, signaling transduction and embryo development. MACF1 is also involved in processes such as metastatic invasion in which cytoskeleton organization is a critical element that contributes to tumor progression in various human cancers. Aberrant expression of MACF1 initiates the tumor cell proliferation, and migration and metastasis in numerous cancers, such as breast cancer, colon cancer, lung cancer and glioblastoma. In this review, we summarized the current knowledge of MACF1 and its critical role in different human cancers. This will be helpful for researchers to investigate the novel functional role of MACF1 in human cancers and as a potential target to enhance the efficacy of therapeutic treatment modalities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据