期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 158, 期 -, 页码 112-118出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.06.038
关键词
Simvastatin delivery; PLGA dimpled microspheres; Silk coating; Alveolar ridge preservation
资金
- Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Human Resources and Social Security [201519205]
- Tianjin Research Program of Application Foundation and Advanced Technology [15JCQNJC14400]
- Science and Technology Development Foundation for Universities in Tianjin [20140135]
- Hospital of Stomatology, Tianjin Medical University [2013YKYQ02]
- Basic Research Fund of State Institutes for Public Career [2016ZX310086]
The surface physical features and chemical components of polymeric particles play an important role in drug delivery systems. In this study, PLGA blank microspheres and simvastatin-loaded PLGA micro spheres with dimpled surface structure were prepared by single emulsion-solvent evaporation method in the absence of any additives. Subsequently, glutaraldehyde cross-linking was optimized for silk fibroin coating on simvastatin-loaded PLGA dimpled microspheres due to good solubility of simvastatin in alcohol. Furthermore, simvastatin release kinetics was investigated for silk-coated or plain PLGA dimpled microspheres. These drug carriers may have potential applications for alveolar ridge preservation with local delivery of simvastatin. (C) 2017 Elsevier B.V. All rights reserved.
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