期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 47, 页码 14898-14902出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201709082
关键词
bioinorganic; cancer; cells; iridium; photosensitizers
资金
- EPSRC [EP/G006792, EP/P001459/1]
- NSFC [21471164, 21525105]
- 973 program [2015CB856301]
- BBSRC [BB/P021875/1] Funding Source: UKRI
- EPSRC [EP/J000302/1, EP/P001459/1, EP/N021630/1] Funding Source: UKRI
Strongly luminescent iridium(III) complexes, [Ir(C,N)(2)(S,S)](+) (1) and [Ir(C,N)(2)(O,O)] (2), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X-ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of O-1(2), with large 2-photon absorption cross-sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub-micromolar doses towards 3D multicellular tumor spheroids with 2-photon red light. Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat-shock protein-70 within living cancer cells. The oxidative stress induced by iridium photosensitizers during photoactivation can increase the levels of enzymes involved in the glycolytic pathway.
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