期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 47, 页码 14968-14972出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708893
关键词
oxidative functionalization; rearrangement; singlet oxygen; tetrahydro--carbolines; visible light
资金
- National Natural Science Foundation of China [81402781]
- Joint Research Project of Health and Education of Fujian Province [WKJ2016-2-06]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- Technology Development Foundation of Fuzhou University
The observation of an unexpected oxidative rearrangement coupling reaction led to the development of a novel method for the efficient functionalization of tetrahydro--carbolines (THCs). The treatment of THCs with photogenerated singlet oxygen (O-1(2)) afforded unstable dioxetanes, which underwent further transformation to form new bonds in the presence of trifluoroacetic acid. This operationally simple protocol exhibits broad functional-group tolerance and is suitable for the late-stage functionalization of complex druglike molecules.
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