期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 47, 页码 15088-15092出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708440
关键词
asymmetric catalysis; C-H activation; chiral Cp ligand; iridium; P-chirality
资金
- Swiss National Science Foundation [157741]
An enantioselective C-H amidation of phosphine oxides by using an iridium(III) catalyst bearing an atropchiral cyclopentadienyl (Cp-x) ligand is reported. A very strong cooperative effect between the chiral Cp-x ligand and a phthaloyl tert-leucine enabled the transformation. Matched-mismatched cases of the different acid enantiomers are shown. The amidated P-chiral arylphosphine oxides are formed in yields of up to 95% and with excellent enantioselectivities of up to 99:1 er. Enantiospecific reduction provides access to valuable P-chiral phosphorus(III) compounds.
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