期刊
DALTON TRANSACTIONS
卷 46, 期 43, 页码 15012-15022出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7dt02584j
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资金
- National Natural Science Foundation of China [21171134, 21573166]
- Natural Science Fund of Hubei Province [2011CDB441]
- Funds for Creative Research Groups of Hubei Province [2014CFA007]
Benzimidazoles are chemically and pharmaceutically important, and an environmentally benign synthetic method based on acceptorless dehydrogenative condensation of primary alcohols and benzene-1,2-diamine is developed in this work. Three Ru(II) hydride complexes [RuHCl(CO)(PNS(O))] (containing two isomers 1a and 1b) and [RuHCl(CO)(PPh3)(SNCNHC)]PF6 (2) based on two new quinoline-based ligands 2-(diphenylphosphanylmethyl)-8-phenylsulfinylquinoline (PNS(O)) and 1-mesityl-3-(8-phenylthioquinolyl-2-methyl)-2-imidazole carbene (SNCNHC) are prepared and fully characterized. These complexes catalyse the condensation of benzyl alcohol and benzene-1,2-diamine to 2-phenylbenzimidazole with the liberation of H-2, and the catalytic activity follows the order: 1a approximate to 1b > 2. When 0.2 mol% of 1a and 2 mol% of NaBPh4 were used, various 2-functionalized benzimidazoles were obtained in good yields (70-85%) and high turnover numbers (TONs similar to 425). This homogeneous system does not need oxidants or stoichiometric strong bases (KOH or (KOBu)-Bu-t, etc.) that are normally used in the reported homogeneous systems, and thus is a greener process.
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