期刊
ANALYTICAL CHEMISTRY
卷 89, 期 22, 页码 12299-12305出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.7b03270
关键词
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资金
- National Natural Science Foundation of China [21301121]
- Beijing talent foundation outstanding young individual project [2015000026833ZK02]
- Beijing Municipal Education Commission
- youth innovative research team of Capital Normal University
Oxidative stress, as an essential cause to many diseases via irreversible biomolecule oxidation, can be induced by casual-contacted nanomaterials, which can generate hydroxyl radical (center dot OH) due to their active surface capacity. Herein, we report a novel upconversion nanoprobe for ratiometric center dot OH detection and monitoring titanium oxide nanomaterial-induced oxidative stress. Unlike previously developed nanoprobes, the center dot OH-responsive acceptor in these nanoprobes can be rapidly prepared and easily recycled. With a detection limit of similar to 2 nM and a broad linear range of 4 nM-16 mu M, the nanoprobe is suitable for both in vitro and in vivo applications. The facile preparation and recyclable strategy provide a new method for developing novel nanoprobes that can directly detect hazardous molecules in biological samples and systems.
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