期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 47, 期 11, 页码 1900-1905出版社
WILEY
DOI: 10.1002/eji.201747063
关键词
Bone marrow; CD8(+) memory T lymphocytes; Cyclophosphamide; Homeostatic proliferation; Tissue resident memory
类别
资金
- European Research Council Advanced Grant IMMEMO [268987, ERC-2010-AdG.20100317]
- DFG Priority Program Immunobone [1468]
- Osteoimmune, a FP7 Marie Curie Initial Training Network [FP7-PEOPLE-2011-ITN-289150]
- state of Berlin
- European Regional Development Fund (ERDF) [EFRE 1.8/11]
- EUTRAIN, FP7 Marie Curie Initial Training Network for Early Stage Researchers - European Union [FP7-PEOPLE-2011-ITN-289903]
It is current belief that numbers of CD8(+) memory T lymphocytes in the memory phase of an immune response are maintained by homeostatic proliferation. Here, we compare the proliferation of CD8(+) memory T lymphocytes, generated by natural infections and by intentional immunization, in spleen and bone marrow (BM). Fifty percent of CD8(+) memory T lymphocytes in the spleen are eliminated by cyclophosphamide within 14 days, indicating that numbers of at least 50% of splenic CD8(+) memory T lymphocytes are maintained by proliferation. The numbers of CD8(+) memory T lymphocytes in the BM, however, were not affected by cyclophosphamide. This stability was independent of circulating CD8(+) memory T cells, blocked by FTY720, showing that BM is a privileged site for the maintenance of memory T lymphocytes, as resident cells, resting in terms of proliferation.
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