期刊
BRAIN STRUCTURE & FUNCTION
卷 222, 期 8, 页码 3665-3676出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-017-1425-z
关键词
Brain functional dynamics; Functional connectivity; Brain functional network; Scaffolding mechanism; Resting-state functional magnetic resonance imaging
资金
- Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme
- NMRC [NMRC/CBRG/0039/2013]
- Singapore Ministry of Education Academic Research Fund Tier 2 [MOE2012-T2-2-130]
- Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore [NMRC/TCR/004-NUS/2008, NMRC/TCR/012-NUHS/2014]
Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain functional dynamics at rest follow the same scaffolding mechanism for aging using a large Chinese sample aged from 22 to 79 years (n = 277). We defined a probability of brain regions being hubs over a period of time to characterize functional hub dynamic, and defined variability of the functional connectivity to characterize dynamic functional connectivity using resting-state fMRI. Our results revealed that both functional hub dynamics and dynamic functional connectivity posited an age-related posterior-to-anterior shift. Specifically, the posterior brain region showed attenuated dynamics, while the anterior brain regions showed augmented dynamics in aging. Interestingly, our analysis further indicated that the age-related episodic memory decline was associated with the age-related decrease in the brain functional dynamics of the posterior regions. Hence, these findings provided a new dimension to view the scaffolding mechanism for aging based on the brain functional dynamics.
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