期刊
ACTA NEUROLOGICA SCANDINAVICA
卷 136, 期 -, 页码 15-17出版社
WILEY
DOI: 10.1111/ane.12845
关键词
axonal injury; biomarkers; cerebrospinal fluid; microglia; multiple sclerosis; plasma; serum
资金
- Swedish Research Council
- European Research Council
- Knut and Alice Wallenberg Foundation
- Wolfson Foundation
- Frimurarestiftelsen
- MRC [UKDRI-1003] Funding Source: UKRI
- Medical Research Council [UKDRI-1003] Funding Source: researchfish
Although it is clear that the immune system is an important disease driver in multiple sclerosis (MS), it is presently unknown what initiates the process. Infections have been mentioned as potential triggers, which is specifically dealt with in other articles of this volume. Here, I give an overview of two fluid biomarkers that reflect key elements of the MS process: microglial activation (cerebrospinal fluid [CSF] sTREM2) and axonal injury (CSF and serum/plasma neurofilament light). I review recent data on how these markers are altered in MS, how they change in relation to disease progression and treatment and, finally, how they can be used as tools in MS research.
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