期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 43, 期 1, 页码 59-68出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2016.07.025
关键词
Transient elastography; Fibroscan; Portal hypertension; Liver stiffness measurement; Chronic liver disease
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2014 R1 A1 A1006823]
- Ministry of Health & Welfare, Republic of Korea [HI14 C1090]
We aimed to evaluate the correlation between liver stiffness measurement using transient elastography (TE-LSM) and hepatic venous pressure gradient and the diagnostic performance of TE-LSM in assessing clinically significant portal hypertension through meta-analysis. Eleven studies were included from thorough literature research and selection processes. The summary correlation coefficient was 0.783 (95% confidence interval [CI], 0.737-0.823). Summary sensitivity, specificity and area under the hierarchical summary receiver operating characteristic curve (AUC) were 87.5% (95% CI, 75.8-93.9%), 85.3%(95% CI, 76.9-90.9%) and 0.9, respectively. The subgroup with low cut-off values of 13.6-18 kPa had better summary estimates (sensitivity 91.2%, specificity 81.3% and partial AUC 0.921) than the subgroup with high cut-off values of 21-25 kPa (sensitivity 71.2%, specificity 90.9% and partial AUC 0.769). In summary, TE-LSM correlated well with hepatic venous pressure gradient and represented good diagnostic performance in diagnosing clinically significant portal hypertension. For use as a sensitive screening tool, we propose using low cut-off values of 13.6-18 kPa in TE-LSM. (E-mail:medimash@gmail.com) (C) 2016 World Federation for Ultrasound in Medicine & Biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据