期刊
ULTRASONICS SONOCHEMISTRY
卷 37, 期 -, 页码 592-599出版社
ELSEVIER
DOI: 10.1016/j.ultsonch.2017.02.020
关键词
Sonodynamic therapy; Sonosensitizer; Malignant glioma; Blood-brain barrier
资金
- National Key Basic Research Program of China (973 Program) [2015CB755500, 2014CB744502]
- National Natural Science Foundation of China [81472846, 81571834]
- China Postdoctoral Science Foundation [2016M600684]
- Fundamental Research Funds for the Central Universities [GK201502009]
Malignant glioma is one of the most challenging central nervous system diseases to treat, and has high rates of recurrence and mortality. The current therapies include surgery, radiation therapy, and chemotherapy, although these approaches often failed to control tumor progression or improve patient survival. Sonodynamic therapy is a developing cancer treatment that uses ultrasound combined with a sonosensitizer to synergistically kill tumor cells, and has provided impressive results in both in vitro and in vivo studies. The ultrasound waves can penetrate deep tissues and reversibly open the blood-brain barrier to enhance drug delivery to the brain. Thus, sonodynamic therapy has a promising potential in glioma treatment. In this review, we summarize the studies that have confirmed the pre-clinical efficacy of sonodynamic therapy for glioma treatment, and discuss the future directions for this emerging treatment. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据