期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 46, 页码 14707-14711出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201709070
关键词
alkenyl boronates; chlorination; divergent synthesis; iterative coupling; stereoselective synthesis
资金
- Key Project of Chinese National Programs for Fundamental Research and Development [2016YFA0602900]
- National Natural Science Foundation of China [81402794, 21472250]
- 1000-Youth Talents Plan
The individual molecules of alpha-chloroalkenyl boronates include both an electrophilic C-Cl bond and a nucleophilic C-B bond, which makes them intriguing organic synthons. Reported herein is a stereodivergent synthesis of both Eand Z alpha-chloroalkenyl N-methyliminodiacetyl (MIDA) boronates through the direct chlorination of alkenyl MIDA boronates using tBuOCl and PhSeCl reagents, respectively. Both reaction processes are stereospecific and the use of sp(3)-B MIDA boronate is the key contributor to the reactivity. The synthetic value of the boronate products was also demonstrated.
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