期刊
ULTRASONICS SONOCHEMISTRY
卷 39, 期 -, 页码 25-33出版社
ELSEVIER
DOI: 10.1016/j.ultsonch.2017.04.007
关键词
Cyclodextrin; Benzyl Isothiocyanate; Thermal and UV stability; Antimicrobial
资金
- DST - India
- INSPIRE
- DST-PURSE-II New Delhi, India
The use of methodical and innovative sonication method has been explored for the fabrication of inclusion complex of Benzyl Isothiocyanate, a potential anticancer and -antimicrobial agent. The advancement involved investigation of inclusion behaviour, characterisation and an in-depth study of thermal and UV stability of Benzyl Isothiocyanate with cyclodextrins; beta-CD and hp-beta-CD. The sonication driven encompassment in cyclodextrins helped to overcome the hindrance of low solubility and high volatility. Investigations of physical and thermodynamic parameters using UV-visible spectroscopy, FTIR, XRD, TGA etc confirmed stability of inclusion complexes. Both beta-CD and hp-beta-CD based inclusion complexes retained the antimicrobial property of the free Benzyl Isothiocyanate, indicating their potential utility as antimicrobial agents. Haematological safety and cellular uptake data gives direction to in-depth analysis for its exploitation of anti-tumour activity.
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