期刊
BIOMEDICAL CHROMATOGRAPHY
卷 31, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/bmc.4016
关键词
In vivo; metabolism; quercetin; ultra-performance liquid chromatography; quadrupole-time-of-flight mass spectrometry
类别
资金
- State Key Program of National Natural Science of China [81430095]
- National Science and Technology Major Projects for 'Major New Drugs Innovation and Development' [2012ZX09101212]
Quercetin, a kind of major flavonoid found in many traditional chinese medicines, is an effective substance for treatments such as lowering blood lipids. However, the studies on quercetin have been mainly focused on its pharmacological effect; the treatment of diseases on a material basis, particularly the metabolites derived from quercetin in vivo, has not been evaluated. In this study, we determined the levels, distributions and types of quercetin's metabolites in plasma, urine, feces and bile of rats after a single oral administration of quercetin at a dose of 80mg/kg, using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS). A total of 36 metabolites of quercetin were identified, including 11 metabolites in plasma, 34 metabolites in urine, 12 metabolites in feces and 21 metabolites in bile. The results showed that phase I metabolites were reduction metabolites and phase II metabolites mainly included glucuronidation, sulfation and methylation metabolites. These results provide important information on the metabolism of quercetin, which will be helpful for its further development and utilization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据