期刊
TUMOR BIOLOGY
卷 39, 期 2, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1010428317692226
关键词
Toxins; antibody; immunotoxins; cancer therapy
类别
Cancer is one of the main reasons of death in the most countries and in Iran. Immunotherapy quickly became one of the best methods of cancer treatment, along with chemotherapy and radiation. Immunotoxin Therapy is a promising way of cancer therapy that is mentioned in this field. Immunotoxins are made from a toxin attaching to an antibody target proteins present on cancer cells. The first-generation immunotoxins were made of a full-length toxin attached to whole monoclonal antibodies. But, these immunotoxins could bind to normal cells. DAB389IL2 was the first immunotoxin approved by the Food and Drug Administration. Current trends and researches are ongoing on finding proteins that in combination with immunotoxins have minimal immunogenicity and the most potency for target cell killing.
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