期刊
JOURNAL OF CANCER PREVENTION
卷 22, 期 4, 页码 203-210出版社
KOREAN SOC CANCER PREVENTION
DOI: 10.15430/JCP.2017.22.4.203
关键词
RNA-binding proteins; Cancer; Chemoprevention; Therapeutics
类别
资金
- National Research Foundation of Korea (NRF) - Korea government [2016R1A2B2008007]
- National Research Foundation of Korea [2016R1A2B2008007] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA binding domains. In development and progression of carcinogenesis, RBPs are aberrantly dysregulated in many human cancers with various mechanisms, such as genetic alteration, epigenetic change, noncoding RNA-mediated regulation, and post-translational modifications. Upon deregulation in cancers, RBPs influence every step in the development and progression of cancer, including sustained cell proliferation, evasion of apoptosis, avoiding immune surveillance, inducing angiogenesis, and activating metastasis. To develop therapeutic strategies targeting RBPs, RNA interference-based oligonucleotides or small molecule inhibitors have been screened based on reduced RBP-RNA interaction and changed level of target RNAs. Identification of binding RNAs with high-throughput techniques and integral analysis of multiple datasets will help us develop new therapeutic drugs or prognostic biomarkers for human cancers.
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