期刊
ACS NANO
卷 11, 期 12, 页码 12087-12093出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b04882
关键词
DNA micelles; structural stability; self-assembly; G-quadruplex; photoirradiation
类别
资金
- NSFC [NSFC 21521063, NSFC 21327009]
- NIH [GM079359]
- NSF [1645215]
- Key Research and Development Program of Shandong Province, China [2015GGH301001]
- Technology Research Project of Shandong Provincial Education Department [J15LC07]
Because of their facile preparation, small size (<100 nm), programmable design, and biocompatibility, lipid-based DNA micelles show enormous potential as a tool to monitor biological events and treat,human diseases. However, their structural stability in biological matrices suffers from spatiotemporal variability, thus limiting their in vivo use. Herein, we have engineered stability-tunable DNA micelle flares using photocontrollable dissociation of intermolecular G-quadruplexes, which confers DNA micelle flares with robust structural stability against disruption by serum albumin. However, once exposed to light, the G-quadruplex formation is blocked by strand hybridization, resulting in the loss of stability in the presence of serum albumin and subsequent cellular uptake. This programmable regulation to stabilize lipid-based micelles in the presence of fatty-acid-binding serum albumin should further the development of biocompatible DNA micelles for in vivo applications.
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