期刊
BIORESOURCE TECHNOLOGY
卷 245, 期 -, 页码 1710-1717出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2017.05.209
关键词
Succinic acid; Renewable resources; Metabolic engineering; NADH/NAD(+); Carbon dioxide
资金
- 973 Program of China [2013CB733902]
- Project of State Key Laboratory of Materials-Oriented Chemical Engineering [KL16-08]
- Key Science and Technology Project of Jiangsu Province [BE2016389]
- Jiangsu Province Natural Science Foundation for Youths [BK20140940]
- Postdoctoral Foundation of Jiangsu Province [1601043B]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Program for Changjiang Scholars and Innovative Research Team in University [06-A-047]
Succinic acid is a four-carbon dicarboxylic acid, which has attracted much interest due to its abroad usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of model strains, and process optimization for succinic acid production have been developed. This review provides an overview of succinic acid producers and cultivation technology, highlight some of the successful metabolic engineering approaches. (C) 2017 Elsevier Ltd. All rights reserved.
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