期刊
DRUG DISCOVERY TODAY
卷 22, 期 12, 页码 1765-1781出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2017.08.001
关键词
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资金
- National Medical Research Council of Singapore
- NUHS
- NCIS
- National Research Foundation Singapore
- Singapore Ministry of Education under its Research Centers of Excellence initiative
Vitamin E family members: tocotrienols and tocopherols are widely known for their health benefits. Decades of research on tocotrienols have shown they have diverse biological activities such as antioxidant, anti-inflammatory, anticancer, neuroprotective and skin protection benefits, as well as improved cognition, bone health, longevity and reduction of cholesterol levels in plasma. Tocotrienols also modulate several intracellular molecular targets and, most importantly, have been shown to improve lipid profiles, reduce total cholesterol and reduce the volume of white matter lesions in human clinical trials. This review provides a comprehensive update on the little-known therapeutic potentials of tocotrienols, which tocopherols lack in a variety of inflammation-driven diseases.
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