期刊
BIOTECHNOLOGY ADVANCES
卷 35, 期 8, 页码 1004-1021出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2017.03.001
关键词
Marine bioactive compounds; Metabolic engineering; Terpenoids; Omega-3 polyunsaturated fatty acids; Marine natural drugs; Squalene; Astaxanthin; Docosahexaenoic acid; Eicosapentaenoic acid
资金
- Intelligent Synthetic Biology Center through the Global Frontier Project of the Ministry of Science, ICT & Future Planning through the National Research Foundation of Korea (NRF) [2011-0031963]
- National Science Foundation of China [31471607]
- International Postdoctoral Exchange Fellowship Program [20140075]
- Korea-China Young Scientist Exchange Program from NRF
Many marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives. (C) 2017 Elsevier Inc. All rights reserved.
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