期刊
ACS NANO
卷 11, 期 12, 页码 12121-12133出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b05182
关键词
controlled colloidal clustering; iron oxide nanocubes; specific absorption rate; poly(styrene-co-maleic anhydride); magnetic hyperthermia; annealing; Monte Carlo simulation
类别
资金
- EU-Initial Training Network Mag(net)icFun [PITN-GA-2012-290248]
- Royal Society International Exchanges Scheme [IE160535]
- European Research Council (ERC) (Starting Grant ICARO project) [678109]
- Xunta de Galicia
- EPSRC doctoral training center grant [EP/G03690X/1]
Magnetic hyperthermia (MH) based on magnetic nanoparticles (MNPs) is a promising adjuvant therapy for cancer treatment. Particle clustering leading to complex magnetic interactions affects the heat generated by MNPs during MH. The heat efficiencies, theoretically predicted, are still poorly understood because of a lack of control of the fabrication of such clusters with defined geometries and thus their functionality. This study aims to correlate the heating efficiency under MH of individually coated iron oxide nanocubes (IONCs) versus soft colloidal nanoclusters made of small groupings of nanocubes arranged in different geometries. The controlled clustering of alkyl-stabilized IONCs is achieved here during the water transfer procedure by tuning the fraction of the amphiphilic copolymer, poly(styrene-co-maleic anhydride) cumene-terminated, to the nanoparticle surface. It is found that increasing the polymer-to-nanoparticle surface ratio leads to the formation of increasingly large nanoclusters with defined geometries. When compared to the individual nanocubes, we show here that controlled grouping of nanoparticles so-called dimers and trimers composed of two and three nanocubes, respectively increases specific absorption rate (SAR) values, while conversely, forming centrosymmetric clusters having more than four nanocubes leads to lower SAR values. Magnetization measurements and Monte Carlo-based simulations support the observed SAP. trend and reveal the importance of the dipolar interaction effect and its dependence on the details of the particle arrangements within the different clusters.
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