期刊
BIOFABRICATION
卷 9, 期 4, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1758-5090/aa90ed
关键词
ceramics; porous scaffolds; microstructure; 3D printing; osteoinductivity
资金
- National Key Research and Development Program of China [2016YFC1102000]
- '111' Project of China [B16033]
- Sichuan Province Major Scientific & Technological Achievements Transformation Demonstration Project [2016CZYD0004]
- Sichuan Province Science & Technology Department key projects [2017SZ0001]
- Science and Technology Support Program of Sichuan Province [2016GZ0196]
- Guangxi Scientific Res and Tech Development Foundation [Guikegong 1598013-15]
Hierarchical porosity, which includes micropores and macropores in scaffolds, contributes to important multiple biological functions for tissue regeneration. This paper introduces a two-step method of combining three-dimensional printing (3DP) and microwave sintering to fabricate two-level hierarchical porous scaffolds. The results showed that 3D printing made the macroporous structure well-controlled and microwave sintering generated micropores on the macropore surface. The resulting hierarchical macro/microporous hydroxyapatite scaffold induced bone formation following intramuscular implantation. Moreover, when comparing the hierarchical macro/microporous hydroxyapatite scaffold to the non-osteoinductive hydroxyapatite scaffolds (either 3D printed or H2O2 foamed) subjected to muffle sintering which do not have micropores, the critical role of micropores in material-driven bone formation was shown. The findings presented herein could be useful for the further optimization of bone grafting materials for bone regeneration.
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