期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 23, 页码 6180-6189出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.12.046
关键词
Continuous flow processing; Active pharmaceutical ingredient; Telescoping; Multistep flow synthesis; In-line analytics; Continuous purification
资金
- Gedeon Richter Talentum Foundation
- Pro Progressio Foundation
Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing processes of pharmaceutical compounds, in accordance with recent regulatory, economical and quality guidances. The chemical and technical knowledge gained during these studies is considerable; nevertheless, connecting several individual chemical transformations and the attached analytics and purification holds hidden traps. In this review, we summarize innovative solutions for these challenges, in order to benefit chemists aiming to exploit flow chemistry systems for the synthesis of biologically active molecules. (C) 2016 Elsevier Ltd. All rights reserved.
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