期刊
BIODRUGS
卷 31, 期 6, 页码 473-481出版社
ADIS INT LTD
DOI: 10.1007/s40259-017-0247-0
关键词
-
资金
- SITC (EMD-Serono Cancer Immunotherapy Clinical Fellowship)
- AACR (Bristol-Myers Squibb Oncology Fellowship in Clinical Cancer Research)
- Gabrielle's Angel Foundation
- SIES-AIL
- ASH Scholar Award
- NCI [K99 CA212302-01A1, K12CA166039]
- Predolin Foundation
- NCCN Young Investigator Award
- Mayo Clinic Center for Individualized Medicine
Autologous, patient-specific chimeric antigen receptor T-cell (CART) therapy has emerged as a powerful and potentially curative therapy for cancer, especially for CD19-positive hematological malignancies. Indeed, on August 30, 2017, the University of Pennsylvania-designed CD19-directed CART (CART-19) cell therapy (CTL019, tisagenlecleucel-t, Kymriah - Novartis) became the first CART therapy approved by the Food and Drug Administration (FDA) for acute lymphoblastic leukemia. However, the development of CART technology and its wider application is partly limited by the patient-specific nature of such a platform and by the time required for manufacturing. The efficacious generation of universal allogeneic CART cells would overcome these limitations and represent a major advance in the field. However, several obstacles in the generation of universal CART cells need to be overcome, namely the risk of CART rejection and the risk of graft-versus-host disease mediated by the allogeneic CART. In this review, we discuss the different strategies being employed to generate universal CART and provide our perspective on the successful development of a truly off-the-shelf CART product.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据