期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 19, 页码 10436-10445出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b01687
关键词
poly(ortho ester); oral chemotherapy; controlled release; surface erosion
资金
- Chinese Program for New Century Excellent Talents in Universities [NCET-11-0661]
- National Natural Science Foundation of China [21174054, 21004030]
- Scientific Research Foundation for Returned Scholars from Ministry of Education of China
- Natural Science Foundation of Anhui Province of China [1408085MB26]
- Academic and Technology Introduction Project of Anhui University of China [AU02303203]
Two new poly(ortho ester amide) copolymers (POEA-4 and POEA-5) Were synthesized via polycondensation of a new ortho ester diamine monomer with active esters of different aliphatic diacids. The kinetics of POEA mass loss and release of 5-FU were both nearly zero:order, suggesting predominantly surface-restricted polymer erosion and drug release. In vitro cytotoxicity tests demonstrated that both copolymers have excellent biocompatibility. In vivo acute toxicity tests suggested that oral administration of POEA-4 and POEA-5 did not cause any adverse effects on mice even at a very high dose (2000 mg/kg). In vivo antitumor efficacy against H22 transplanted tumors of 5-FU-loaded POEA tablets were fully examined. We with further optimization, POEA-based materials could have great potential as drug carriers for oral chemotherapy.
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