期刊
ANIMAL SCIENCE JOURNAL
卷 88, 期 12, 页码 1889-1901出版社
WILEY
DOI: 10.1111/asj.12851
关键词
African cattle; positive selection signature; thermotolerance; XP-CLR; XP-EHH
资金
- Agenda of the National Institute of Animal Science, Rural Development Administration (RDA), Korea [PJ01134905]
- Biotechnology and Biological Sciences Research Council [BBS/E/D/30002275, BBS/E/D/10002070] Funding Source: researchfish
As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light-colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross-population composite likelihood ratio (XP-CLR) and cross-population extended haplotype homozygosity (XP-EHH) statistical methods. We identified 296 (XP-EHH) and 327 (XP-CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study.
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