期刊
METABOLITES
卷 7, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/metabo7040056
关键词
bacterial carbonic anhydrases; inhibitors; antibiotic; CO2 capture; engineered bacteria
资金
- FP7 European Union Project [HEALTH-F2-2010-261460]
Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the alpha-, beta-, and gamma- classes. By equilibrating CO2 and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO2 capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action.
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