期刊
ACS NANO
卷 11, 期 12, 页码 12134-12144出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b05214
关键词
light-responsive nanoparticles; micelles; cytoplasmic delivery; phototherrnal therapy; synergistic therapy
类别
资金
- National Basic Research Program [2014CB931900]
- National Natural Science Foundation of China [31671016, 51473109, 51503139, 31422021, 31500811]
- Natural Science Foundation of Jiangsu Province of China [BK20150324]
- Natural Science Foundation for Colleges and Universities in Jiangsu Province of China [15KJB150025]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration of stimuli-responsive nanoparticles for fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive nanoparticles were rationally designed to generate highly efficient cytoplasmic delivery of anticancer agents for synergistic thermo-chemotherapy. The drug-loaded polymeric nanoparticles of selenium-inserted copolymer (I/D-Se-NPs) were rapidly dissociated in several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation of I/D-Se-NPs upon such a short irradiation promoted continuous drug release. Moreover, I/D-Se-NPs facilitated cytoplasmic drug translocation through ROS-triggered lysosomal disruption and thus resulted in highly preferable distribution to the nucleus even in 5 min postirradiation, which was further integrated with light-triggered hyperthermia for achieving synergistic tumor ablation without tumor regrowth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据