期刊
DYES AND PIGMENTS
卷 147, 期 -, 页码 270-282出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2017.08.023
关键词
Photodynamic therapy; Photothermal therapy; Diketopyrrolopyrrole; Thieno[2,3-b]indole
资金
- NNSFC [61525402, 61604071]
- Sci-tech Support Plan of Jiangsu Province [BE2014719]
- Key University Science Research Project of Jiangsu Province [15KJA430006]
- Natural Science Foundation of Jiangsu Province [BK20161012]
Synthesis of photodynamic and photothermal agents with absorption in the near-infrared (NIR) region and featuring excellent photostability, high singlet oxygen generation efficiency, good photothermal conversion efficiency, and good biocompatibility is necessary for the application of photodynamic therapy (PDT) and phtothermal therapy (PTT). Three NIR absorption compounds based on thieno[2,3-b] indole (TI) and diketopyrrolopyrrole (DPP) were designed and synthesized. Their UV-vis-NIR absorption, photoluminescence, electronic distribution, energy levels and thermally induced phase transitions have been carefully determined. As structural analogues, only DPP-TI possesses excellent singlet oxygen quantum yield (O-1(2), Phi(Delta) = 48.5%), which displays effective photothermal conversion efficiency (q = 15.8%) as nanoparticles in water. The potential of DPP-TI nanoparticles as fluorescence imaging therapeutic agent for synergetic PDT and PTT in vitro using only one wavelength light were explored preliminarily. (C) 2017 Elsevier Ltd. All rights reserved.
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