期刊
TRENDS IN PLANT SCIENCE
卷 22, 期 3, 页码 204-214出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2016.11.015
关键词
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资金
- Gatsby Charitable Foundation
- European Research Council (ERC)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Deutsche Forschungsgemeinschaft (DFG) [KE 2060/1-1]
- John Innes Foundation
Selective autophagy is a conserved homeostatic pathway that involves engulfment of specific cargo molecules into specialized organelles called autophagosomes. The ubiquitin-like protein ATG8 is a central player of the autophagy network that decorates autophagosomes and binds to numerous cargo receptors. Although highly conserved across eukaryotes, ATG8 diversified from a single protein in algae to multiple isoforms in higher plants. We present a phylogenetic overview of 376 ATG8 proteins across the green plant lineage that revealed family -specific ATG8 clades. Because these clades differ in fixed amino acid polymorphisms, they provide a mechanistic framework to test whether distinct ATG8 clades are functionally specialized. We propose that ATG8 expansion may have contributed to the diversification of selective autophagy pathways in plants.
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