期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 38, 期 4, 页码 406-424出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2017.01.003
关键词
-
资金
- AFM - Telethon [16177, 18221]
- Italian Ministry of Health [RF 2009-1506142]
The presence of cell and tissue barriers together with the low biomembrane permeability of various therapeutics often hampers systemic drug distribution; thus, most of the available molecules are of limited therapeutic value. Opportunities to increase medicament concentrations in areas that are difficult to access now exist with the advent of cell-penetrating peptides (CPPs), which can transport into the cell a wide variety of biologically active conjugates (cargoes). Numerous preclinical evaluations with CPP-derived therapeutics have provided promising results in various disease models that, in some cases, prompted clinical trials. The outcome of these investigations has thus opened new perspectives for CPP application in the development of unprecedented human therapies that are well tolerated and directed to intracellular targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据