期刊
CHEMICAL RECORD
卷 17, 期 12, 页码 1213-1230出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201700019
关键词
DNA nanostructure; DNA nanotechnology; imaging; theranostic; biomedicine
资金
- National Basic Research Program of China [2016YFA0201200]
- National Natural Science Foundation of China [21329501, 21675167, U1532119, 21505148]
A critical challenge in nanotechnology is the limited precision and controllability of the structural parameters, which brings about concerns in uniformity, reproducibility and performance. Self-assembled DNA nanostructures, as a newly emerged type of nano-biomaterials, possess low-nanometer precision, excellent programmability and addressability. They can precisely arrange various molecules and materials to formspatially ordered complex, resulting in unambiguous physical or chemical properties.Because of these, DNA nanostructures have shown great promise in numerous biomedical theranostic applications. In this account, we briefly review the history and advances on construction of DNA nanoarchitectures and superstructures with accurate structural parameters. We focus on recent progress in exploiting these DNA nanostructures as platforms for quantitative biosensing, intracellular diagnosis, imaging, and smart drug delivery. We also discuss key challenges in practical applications.
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