Recent Advances and Perspectives of Transition Metal-Catalyzed Asymmetric Fluorination Reactions

The synthesis of fluorine-containing molecules has received intensive attention in recent years due to the great value of fluorides, however, the transition metal-catalyzed asymmetric construction of CF bonds is much less developed. This review presents the recent advancement of transition metal-catalyzed asymmetric fluorination reactions, in which the final CF bond is from reductive elimination of organometallic complexes. In addition, the perspective of the field is also provided for the future studies of asymmetric fluorinations and the related transformations, such as trifluoromethylation, trifluoromethylthiolation and trifluoromethoxylation.