4.3 Review

Prospects for adoptive T-cell therapy for invasive fungal disease

期刊

CURRENT OPINION IN INFECTIOUS DISEASES
卷 30, 期 6, 页码 518-527

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QCO.0000000000000403

关键词

allogeneic stem cell transplant; Aspergillus spp.; Candida spp.; fungus; immunity; mould; T cell; yeast

资金

  1. National Health and Medical Research Council of Australia
  2. Leukaemia Foundation of Australia
  3. Cancer Council of New South Wales

向作者/读者索取更多资源

Purpose of review Invasive fungal disease (IFD) is a cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. As more potent broad-spectrum antifungal agents are used in prophylaxis, drug resistance and less common fungal species have increased in frequency. Here we review current treatments available for IFD and examine the potential for adoptive T-cell treatment to enhance current therapeutic choices in IFD. Recent findings There is growing evidence supporting the role of T cells as well as phagocytes in antifungal immunity. T cells recognizing specific antigens expressed on fungal morphotypes have been identified and the role of T-cell transfer has been explored in animal models. The clinical efficacy of adoptive transfer of antigen specific T cells for prophylaxis and treatment of viral infections post-HSCT has raised interest in developing good manufacturing practice (GMP)-compliant methods for manufacturing and testing fungus-specific T cells after HSCT. Summary As the outcomes of IFD post-HSCT are poor, reconstitution of antifungal immunity offers a way to correct the underlying deficiency that has caused the infection rather than simply pharmacologically suppress fungal growth. The clinical development of fungus specific T cells is in its early stages and clinical trials are needed in order to evaluate safety and efficacy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据