期刊
TRENDS IN NEUROSCIENCES
卷 40, 期 7, 页码 422-437出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2017.05.002
关键词
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资金
- CHDI [A-7815]
- NIH [NS060677, MH099559, MH104069]
- German Research Council [Exc 257/1]
- Charite Research Funds [2016-040]
- NIMH
- NINDS
- Novo Nordisk Foundation
- Lundbeck Foundation
- Adelson Medical Research Foundation
- Mathers Foundation
- ALS Association
- Lundbeck Foundation [R155-2016-553] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0004260] Funding Source: researchfish
Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as well as on the use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD. Overall, the data suggest that astrocyte dysfunction is an important contributor to the onset and progression of some HD symptoms in mice. Additional exploration of astrocytes in HD mouse models and humans is needed and may provide new therapeutic opportunities to explore in conjunction with neuronal rescue and repair strategies.
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